MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2

The respiratory system is one of the most affected targets SARS-CoV-2. Various therapies have been utilized to counter viral-induced inflammatory complications, with diverse success rates. Pending distribution an effective vaccine whole population and achievement “herd immunity”, discovery novel specific be considered a very important objective. Here, we report computational study demonstrating existence target motifs in SARS-CoV-2 genome suitable for binding endogenous human micro long non-coding RNAs (miRNAs lncRNAs, respectively), which can, therefore, conceptual background development miRNA-based drugs against COVID-19. contains three 5?UTR leader sequence recognized by selective nucleotides within seed miRNAs. 57 microRNAs contained “GGG” motif that promoted sequence-recognition, primarily through offset-6mer sites able promote noncanonical viral RNA. Similarly, lncRNA H19 binds and, more specifically, transcript gene Spike, has pivotal role infection. Notably, some identified our as candidates inhibiting expression already proposed infections, pulmonary arterial hypertension, related diseases.